![]() For specific advice on goals and management, see published guidelines, such as those of the National High Blood Pressure Education Program’s Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC). Many patients will require more than 1 drug to achieve blood pressure goals. ![]() These benefits have been seen in controlled trials of antihypertensive drugs from a wide variety of pharmacologic classes including metoprolol.Ĭontrol of high blood pressure should be part of comprehensive cardiovascular risk management, including, as appropriate, lipid control, diabetes management, antithrombotic therapy, smoking cessation, exercise, and limited sodium intake. Lowering blood pressure lowers the risk of fatal and non-fatal cardiovascular events, primarily strokes and myocardial infarctions. Metoprolol Succinate Extended-Release Tablets are indicated for the treatment of hypertension, to lower blood pressure. Metoprolol can pass into breast milk and may cause dry skin, dry mouth, diarrhea, constipation, or slow heartbeats in your baby.FULL PRESCRIBING INFORMATION: CONTENTS * 1 INDICATIONS AND USAGE 1.1 Hypertension 1.2 Angina Pectoris 1.3 Heart Failure 2 DOSAGE AND ADMINISTRATION 2.1 Hypertension 2.2 Angina Pectoris 2.3 Heart Failure 2.4 Administration 3 DOSAGE FORMS AND STRENGTHS 4 CONTRAINDICATIONS 5 WARNINGS AND PRECAUTIONS 5.1 Abrupt Cessation of Therapy 5.2 Heart Failure 5.3 Bronchospastic Disease 5.4 Bradycardia 5.5 Pheochromocytoma 5.6 Major Surgery 5.7 Mask Symptoms of Hypoglycemia 5.8 Thyrotoxicosis 5.9 Peripheral Vascular Disease 5.10 Anaphylactic Reaction 6 ADVERSE REACTIONS 6.1 Clinical Trials Experience 6.2 Post-Marketing Experience 7 DRUG INTERACTIONS 7.1 Catecholamine Depleting Drugs 7.2 CYP2D6 Inhibitors 7.3 Digitalis, Clonidine, and Calcium Channel Blockers 8 USE IN SPECIFIC POPULATIONS 8.1 Pregnancy 8.2 Lactation 8.3 Females and Males of Reproductive Potential 8.4 Pediatric Use 8.5 Geriatric Use 8.6 Hepatic Impairment 8.7 Renal Impairment 10 OVERDOSAGE 11 DESCRIPTION 12 CLINICAL PHARMACOLOGY 12.1 Mechanism of Action 12.2 Pharmacodynamics 12.3 Pharmacokinetics 12.5 Pharmacogenomics 13 NONCLINICAL TOXICOLOGY 13.1 Carcinogenesis, Mutagenesis, Impairment of Fertility 14 CLINICAL STUDIES 14.1 Hypertension 14.2 Angina Pectoris 14.3 Heart Failure 16 HOW SUPPLIED/STORAGE AND HANDLING 17 PATIENT COUNSELING INFORMATION * Sections or subsections omitted from the full prescribing information are not listed. The benefit of treating hypertension may outweigh any risks to the baby.Īsk a doctor before using this medicine if you are breast-feeding. However, having high blood pressure during pregnancy may cause complications such as diabetes or eclampsia (dangerously high blood pressure that can lead to medical problems in both mother and baby). It is not known whether metoprolol will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. pheochromocytoma (tumor of the adrenal gland).ĭo not give this medicine to a child without medical advice.problems with circulation (such as Raynaud's syndrome).diabetes (taking metoprolol may make it harder for you to tell when you have low blood sugar).asthma, chronic obstructive pulmonary disease (COPD), sleep apnea, or other breathing disorder.a history of slow heart beats that have caused you to faint.severe heart failure (that required you to be in the hospital) or.a serious heart problem such as heart block, sick sinus syndrome, or slow heart rate. ![]() You should not use this medicine if you are allergic to metoprolol, or other beta-blockers (atenolol, carvedilol, labetalol, nadolol, nebivolol, propranolol, sotalol, and others), or if you have:
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